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trem2 protein levels  (R&D Systems)


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    R&D Systems trem2 protein levels
    A . Flowchart describing selection of gene markers associated with a high-risk of progression to late AMD for validation, based on bulk RNAseq of the macular RPE/choroid. B. A heatmap showing high-risk marker gene expression in the macular RPE/choroid in samples of AMD1, AMD3L, and AMD3H. The levels of each mRNA are expressed as log 2 (TPM+1), where TPM stands for transcript per million, red indicates positive value and blue negative. C . Representative RNAscope images of C3 mRNA in AMD1, AMD3L, AMD3H, and AMD4/GA macula sections, with arrows indicating C3 mRNA + signals. C3 increases in the RPE-adjacent region with disease severity. D. Representative RNAscope images of <t>TREM2</t> mRNA in AMD1, AMD3L, AMD3H, and AMD4/GA macula sections, with arrows indicating TREM2 mRNA+ signals. TREM2 mRNA becomes apparent in the choroid at AMD3H and persists in AMD4. E. ELISA measurement of TREM2 protein in AMD1 (n = 8 samples) and AMD4 (n = 6-8) in serum, macular and peripheral RPE/choroid tissue and neuroretina, vitreous, and aqueous humor. Donor information is in . The pM label indicates picomolar concentrations, with p value determined by unpaired Student’s t-test (* p < 0.05, *** P <0.001). F . Representative RNAscope images of OLR1 mRNA in AMD1, AMD3L, AMD3H, and AMD4/GA macula sections, with arrows indicating OLR1 mRNA+ signals. OLR1 increases in the RPE-adjacent region with disease severity. G . Representative RNAscope images of NGFR mRNA in AMD1, AMD3L, AMD3H, and AMD4/GA macula sections, with arrows indicating NGFR mRNA+ signals. Elevated NGFR signal is observed in AMD3H, proximal to the RPE.
    Trem2 Protein Levels, supplied by R&D Systems, used in various techniques. Bioz Stars score: 93/100, based on 5 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/trem2 protein levels/product/R&D Systems
    Average 93 stars, based on 5 article reviews
    trem2 protein levels - by Bioz Stars, 2026-05
    93/100 stars

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    1) Product Images from "Identification of cellular and molecular risk signatures for progression to late-stage age-related macular degeneration using the 9-step Minnesota Grading System"

    Article Title: Identification of cellular and molecular risk signatures for progression to late-stage age-related macular degeneration using the 9-step Minnesota Grading System

    Journal: bioRxiv

    doi: 10.1101/2025.07.10.664209

    A . Flowchart describing selection of gene markers associated with a high-risk of progression to late AMD for validation, based on bulk RNAseq of the macular RPE/choroid. B. A heatmap showing high-risk marker gene expression in the macular RPE/choroid in samples of AMD1, AMD3L, and AMD3H. The levels of each mRNA are expressed as log 2 (TPM+1), where TPM stands for transcript per million, red indicates positive value and blue negative. C . Representative RNAscope images of C3 mRNA in AMD1, AMD3L, AMD3H, and AMD4/GA macula sections, with arrows indicating C3 mRNA + signals. C3 increases in the RPE-adjacent region with disease severity. D. Representative RNAscope images of TREM2 mRNA in AMD1, AMD3L, AMD3H, and AMD4/GA macula sections, with arrows indicating TREM2 mRNA+ signals. TREM2 mRNA becomes apparent in the choroid at AMD3H and persists in AMD4. E. ELISA measurement of TREM2 protein in AMD1 (n = 8 samples) and AMD4 (n = 6-8) in serum, macular and peripheral RPE/choroid tissue and neuroretina, vitreous, and aqueous humor. Donor information is in . The pM label indicates picomolar concentrations, with p value determined by unpaired Student’s t-test (* p < 0.05, *** P <0.001). F . Representative RNAscope images of OLR1 mRNA in AMD1, AMD3L, AMD3H, and AMD4/GA macula sections, with arrows indicating OLR1 mRNA+ signals. OLR1 increases in the RPE-adjacent region with disease severity. G . Representative RNAscope images of NGFR mRNA in AMD1, AMD3L, AMD3H, and AMD4/GA macula sections, with arrows indicating NGFR mRNA+ signals. Elevated NGFR signal is observed in AMD3H, proximal to the RPE.
    Figure Legend Snippet: A . Flowchart describing selection of gene markers associated with a high-risk of progression to late AMD for validation, based on bulk RNAseq of the macular RPE/choroid. B. A heatmap showing high-risk marker gene expression in the macular RPE/choroid in samples of AMD1, AMD3L, and AMD3H. The levels of each mRNA are expressed as log 2 (TPM+1), where TPM stands for transcript per million, red indicates positive value and blue negative. C . Representative RNAscope images of C3 mRNA in AMD1, AMD3L, AMD3H, and AMD4/GA macula sections, with arrows indicating C3 mRNA + signals. C3 increases in the RPE-adjacent region with disease severity. D. Representative RNAscope images of TREM2 mRNA in AMD1, AMD3L, AMD3H, and AMD4/GA macula sections, with arrows indicating TREM2 mRNA+ signals. TREM2 mRNA becomes apparent in the choroid at AMD3H and persists in AMD4. E. ELISA measurement of TREM2 protein in AMD1 (n = 8 samples) and AMD4 (n = 6-8) in serum, macular and peripheral RPE/choroid tissue and neuroretina, vitreous, and aqueous humor. Donor information is in . The pM label indicates picomolar concentrations, with p value determined by unpaired Student’s t-test (* p < 0.05, *** P <0.001). F . Representative RNAscope images of OLR1 mRNA in AMD1, AMD3L, AMD3H, and AMD4/GA macula sections, with arrows indicating OLR1 mRNA+ signals. OLR1 increases in the RPE-adjacent region with disease severity. G . Representative RNAscope images of NGFR mRNA in AMD1, AMD3L, AMD3H, and AMD4/GA macula sections, with arrows indicating NGFR mRNA+ signals. Elevated NGFR signal is observed in AMD3H, proximal to the RPE.

    Techniques Used: Selection, Biomarker Discovery, Marker, Gene Expression, RNAscope, Enzyme-linked Immunosorbent Assay

    Fibroblasts predominantly express C3, immune cells show C3, OLR1 and TREM2 expression, and GFAP, NGFR, SPP1 and GPX2 are expressed in Muller glia and astrocytes.
    Figure Legend Snippet: Fibroblasts predominantly express C3, immune cells show C3, OLR1 and TREM2 expression, and GFAP, NGFR, SPP1 and GPX2 are expressed in Muller glia and astrocytes.

    Techniques Used: Expressing

    A . A dot plot of TREM2 and OLR1 expression in all detected RPE/choroid cell types. Both TREM2 and OLR2 are preferentially expressed in choroidal macrophages. Of the three clusters of macrophages, TREM2 is expressed in macrophage 1 and 3 while OLR1 is expressed in macrophage 2 and 3. B . Dual genes plot of all 3 macrophage populations expressing TREM2 (green dots) versus OLR1 (red dots). There are very few macrophages (yellow dots) expressing both TREM2 and OLR1 .
    Figure Legend Snippet: A . A dot plot of TREM2 and OLR1 expression in all detected RPE/choroid cell types. Both TREM2 and OLR2 are preferentially expressed in choroidal macrophages. Of the three clusters of macrophages, TREM2 is expressed in macrophage 1 and 3 while OLR1 is expressed in macrophage 2 and 3. B . Dual genes plot of all 3 macrophage populations expressing TREM2 (green dots) versus OLR1 (red dots). There are very few macrophages (yellow dots) expressing both TREM2 and OLR1 .

    Techniques Used: Expressing

    In AMD3H, complement C3 can be induced in multiple neuronal and choroidal cell-types including fibroblasts, macrophages, and Müller/astrocytes. Macrophages expressing either TREM2 or OLR1 are observed near the RPE/choriocapillaris complex in AMD3H, possibly originating from the choroid and/or from the systemic circulation, and later in AMD3H/4 outer retina. Activated Müller/astrocytes cells expressing NGFR and GFAP expand from the inner retina to outer retina and RPE in AMD3H. Activation of complement, macrophages, and Müller/astrocytes may signal the onset of the end stage AMD. Graphic was created with Biorender ( biorender.com ).
    Figure Legend Snippet: In AMD3H, complement C3 can be induced in multiple neuronal and choroidal cell-types including fibroblasts, macrophages, and Müller/astrocytes. Macrophages expressing either TREM2 or OLR1 are observed near the RPE/choriocapillaris complex in AMD3H, possibly originating from the choroid and/or from the systemic circulation, and later in AMD3H/4 outer retina. Activated Müller/astrocytes cells expressing NGFR and GFAP expand from the inner retina to outer retina and RPE in AMD3H. Activation of complement, macrophages, and Müller/astrocytes may signal the onset of the end stage AMD. Graphic was created with Biorender ( biorender.com ).

    Techniques Used: Expressing, Activation Assay


    Figure Legend Snippet:

    Techniques Used: Enzyme-linked Immunosorbent Assay



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    trem2 protein levels  (R&D Systems)
    93
    R&D Systems trem2 protein levels
    A . Flowchart describing selection of gene markers associated with a high-risk of progression to late AMD for validation, based on bulk RNAseq of the macular RPE/choroid. B. A heatmap showing high-risk marker gene expression in the macular RPE/choroid in samples of AMD1, AMD3L, and AMD3H. The levels of each mRNA are expressed as log 2 (TPM+1), where TPM stands for transcript per million, red indicates positive value and blue negative. C . Representative RNAscope images of C3 mRNA in AMD1, AMD3L, AMD3H, and AMD4/GA macula sections, with arrows indicating C3 mRNA + signals. C3 increases in the RPE-adjacent region with disease severity. D. Representative RNAscope images of <t>TREM2</t> mRNA in AMD1, AMD3L, AMD3H, and AMD4/GA macula sections, with arrows indicating TREM2 mRNA+ signals. TREM2 mRNA becomes apparent in the choroid at AMD3H and persists in AMD4. E. ELISA measurement of TREM2 protein in AMD1 (n = 8 samples) and AMD4 (n = 6-8) in serum, macular and peripheral RPE/choroid tissue and neuroretina, vitreous, and aqueous humor. Donor information is in . The pM label indicates picomolar concentrations, with p value determined by unpaired Student’s t-test (* p < 0.05, *** P <0.001). F . Representative RNAscope images of OLR1 mRNA in AMD1, AMD3L, AMD3H, and AMD4/GA macula sections, with arrows indicating OLR1 mRNA+ signals. OLR1 increases in the RPE-adjacent region with disease severity. G . Representative RNAscope images of NGFR mRNA in AMD1, AMD3L, AMD3H, and AMD4/GA macula sections, with arrows indicating NGFR mRNA+ signals. Elevated NGFR signal is observed in AMD3H, proximal to the RPE.
    Trem2 Protein Levels, supplied by R&D Systems, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/trem2 protein levels/product/R&D Systems
    Average 93 stars, based on 1 article reviews
    trem2 protein levels - by Bioz Stars, 2026-05
    93/100 stars
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    A . Flowchart describing selection of gene markers associated with a high-risk of progression to late AMD for validation, based on bulk RNAseq of the macular RPE/choroid. B. A heatmap showing high-risk marker gene expression in the macular RPE/choroid in samples of AMD1, AMD3L, and AMD3H. The levels of each mRNA are expressed as log 2 (TPM+1), where TPM stands for transcript per million, red indicates positive value and blue negative. C . Representative RNAscope images of C3 mRNA in AMD1, AMD3L, AMD3H, and AMD4/GA macula sections, with arrows indicating C3 mRNA + signals. C3 increases in the RPE-adjacent region with disease severity. D. Representative RNAscope images of TREM2 mRNA in AMD1, AMD3L, AMD3H, and AMD4/GA macula sections, with arrows indicating TREM2 mRNA+ signals. TREM2 mRNA becomes apparent in the choroid at AMD3H and persists in AMD4. E. ELISA measurement of TREM2 protein in AMD1 (n = 8 samples) and AMD4 (n = 6-8) in serum, macular and peripheral RPE/choroid tissue and neuroretina, vitreous, and aqueous humor. Donor information is in . The pM label indicates picomolar concentrations, with p value determined by unpaired Student’s t-test (* p < 0.05, *** P <0.001). F . Representative RNAscope images of OLR1 mRNA in AMD1, AMD3L, AMD3H, and AMD4/GA macula sections, with arrows indicating OLR1 mRNA+ signals. OLR1 increases in the RPE-adjacent region with disease severity. G . Representative RNAscope images of NGFR mRNA in AMD1, AMD3L, AMD3H, and AMD4/GA macula sections, with arrows indicating NGFR mRNA+ signals. Elevated NGFR signal is observed in AMD3H, proximal to the RPE.

    Journal: bioRxiv

    Article Title: Identification of cellular and molecular risk signatures for progression to late-stage age-related macular degeneration using the 9-step Minnesota Grading System

    doi: 10.1101/2025.07.10.664209

    Figure Lengend Snippet: A . Flowchart describing selection of gene markers associated with a high-risk of progression to late AMD for validation, based on bulk RNAseq of the macular RPE/choroid. B. A heatmap showing high-risk marker gene expression in the macular RPE/choroid in samples of AMD1, AMD3L, and AMD3H. The levels of each mRNA are expressed as log 2 (TPM+1), where TPM stands for transcript per million, red indicates positive value and blue negative. C . Representative RNAscope images of C3 mRNA in AMD1, AMD3L, AMD3H, and AMD4/GA macula sections, with arrows indicating C3 mRNA + signals. C3 increases in the RPE-adjacent region with disease severity. D. Representative RNAscope images of TREM2 mRNA in AMD1, AMD3L, AMD3H, and AMD4/GA macula sections, with arrows indicating TREM2 mRNA+ signals. TREM2 mRNA becomes apparent in the choroid at AMD3H and persists in AMD4. E. ELISA measurement of TREM2 protein in AMD1 (n = 8 samples) and AMD4 (n = 6-8) in serum, macular and peripheral RPE/choroid tissue and neuroretina, vitreous, and aqueous humor. Donor information is in . The pM label indicates picomolar concentrations, with p value determined by unpaired Student’s t-test (* p < 0.05, *** P <0.001). F . Representative RNAscope images of OLR1 mRNA in AMD1, AMD3L, AMD3H, and AMD4/GA macula sections, with arrows indicating OLR1 mRNA+ signals. OLR1 increases in the RPE-adjacent region with disease severity. G . Representative RNAscope images of NGFR mRNA in AMD1, AMD3L, AMD3H, and AMD4/GA macula sections, with arrows indicating NGFR mRNA+ signals. Elevated NGFR signal is observed in AMD3H, proximal to the RPE.

    Article Snippet: Total TREM2 protein levels were measured using a TREM2 Duoset (R&D Systems, Minneapolis, MN) ELISA kit for MSD-based assays (MSD, Rockville, MD) and read on a Sector S 600 imager.

    Techniques: Selection, Biomarker Discovery, Marker, Gene Expression, RNAscope, Enzyme-linked Immunosorbent Assay

    Fibroblasts predominantly express C3, immune cells show C3, OLR1 and TREM2 expression, and GFAP, NGFR, SPP1 and GPX2 are expressed in Muller glia and astrocytes.

    Journal: bioRxiv

    Article Title: Identification of cellular and molecular risk signatures for progression to late-stage age-related macular degeneration using the 9-step Minnesota Grading System

    doi: 10.1101/2025.07.10.664209

    Figure Lengend Snippet: Fibroblasts predominantly express C3, immune cells show C3, OLR1 and TREM2 expression, and GFAP, NGFR, SPP1 and GPX2 are expressed in Muller glia and astrocytes.

    Article Snippet: Total TREM2 protein levels were measured using a TREM2 Duoset (R&D Systems, Minneapolis, MN) ELISA kit for MSD-based assays (MSD, Rockville, MD) and read on a Sector S 600 imager.

    Techniques: Expressing

    A . A dot plot of TREM2 and OLR1 expression in all detected RPE/choroid cell types. Both TREM2 and OLR2 are preferentially expressed in choroidal macrophages. Of the three clusters of macrophages, TREM2 is expressed in macrophage 1 and 3 while OLR1 is expressed in macrophage 2 and 3. B . Dual genes plot of all 3 macrophage populations expressing TREM2 (green dots) versus OLR1 (red dots). There are very few macrophages (yellow dots) expressing both TREM2 and OLR1 .

    Journal: bioRxiv

    Article Title: Identification of cellular and molecular risk signatures for progression to late-stage age-related macular degeneration using the 9-step Minnesota Grading System

    doi: 10.1101/2025.07.10.664209

    Figure Lengend Snippet: A . A dot plot of TREM2 and OLR1 expression in all detected RPE/choroid cell types. Both TREM2 and OLR2 are preferentially expressed in choroidal macrophages. Of the three clusters of macrophages, TREM2 is expressed in macrophage 1 and 3 while OLR1 is expressed in macrophage 2 and 3. B . Dual genes plot of all 3 macrophage populations expressing TREM2 (green dots) versus OLR1 (red dots). There are very few macrophages (yellow dots) expressing both TREM2 and OLR1 .

    Article Snippet: Total TREM2 protein levels were measured using a TREM2 Duoset (R&D Systems, Minneapolis, MN) ELISA kit for MSD-based assays (MSD, Rockville, MD) and read on a Sector S 600 imager.

    Techniques: Expressing

    In AMD3H, complement C3 can be induced in multiple neuronal and choroidal cell-types including fibroblasts, macrophages, and Müller/astrocytes. Macrophages expressing either TREM2 or OLR1 are observed near the RPE/choriocapillaris complex in AMD3H, possibly originating from the choroid and/or from the systemic circulation, and later in AMD3H/4 outer retina. Activated Müller/astrocytes cells expressing NGFR and GFAP expand from the inner retina to outer retina and RPE in AMD3H. Activation of complement, macrophages, and Müller/astrocytes may signal the onset of the end stage AMD. Graphic was created with Biorender ( biorender.com ).

    Journal: bioRxiv

    Article Title: Identification of cellular and molecular risk signatures for progression to late-stage age-related macular degeneration using the 9-step Minnesota Grading System

    doi: 10.1101/2025.07.10.664209

    Figure Lengend Snippet: In AMD3H, complement C3 can be induced in multiple neuronal and choroidal cell-types including fibroblasts, macrophages, and Müller/astrocytes. Macrophages expressing either TREM2 or OLR1 are observed near the RPE/choriocapillaris complex in AMD3H, possibly originating from the choroid and/or from the systemic circulation, and later in AMD3H/4 outer retina. Activated Müller/astrocytes cells expressing NGFR and GFAP expand from the inner retina to outer retina and RPE in AMD3H. Activation of complement, macrophages, and Müller/astrocytes may signal the onset of the end stage AMD. Graphic was created with Biorender ( biorender.com ).

    Article Snippet: Total TREM2 protein levels were measured using a TREM2 Duoset (R&D Systems, Minneapolis, MN) ELISA kit for MSD-based assays (MSD, Rockville, MD) and read on a Sector S 600 imager.

    Techniques: Expressing, Activation Assay

    Journal: bioRxiv

    Article Title: Identification of cellular and molecular risk signatures for progression to late-stage age-related macular degeneration using the 9-step Minnesota Grading System

    doi: 10.1101/2025.07.10.664209

    Figure Lengend Snippet:

    Article Snippet: Total TREM2 protein levels were measured using a TREM2 Duoset (R&D Systems, Minneapolis, MN) ELISA kit for MSD-based assays (MSD, Rockville, MD) and read on a Sector S 600 imager.

    Techniques: Enzyme-linked Immunosorbent Assay